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DMPK Scientist (m/f/d)

Country:  Germany
City:  Aachen
Department:  Research & Development
Job ID:  37035


If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the live of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.


What the job looks like
Each day you'll enjoy a variety of challenges, such as:

  • You serve as DMPK project representative on global discovery and development programs
  • You provide metabolism and drug-drug interaction guidance to discovery project teams to mitigate issues such as “soft spot identification,” “major metabolites” to enable identification of high quality “first in man” candidates
  • You lead the interpretation of metabolite ID studies conducted at CROs and serve as internal expert on structure elucidation, metabolic pathways and reactive metabolite formation
  • You serve as bio-transformation subject matter expert providing expert guidance on metabolic pathways of small molecules and alternate modalities such as anti-sense oligonucleotides, peptides, etc.
  • You demonstrate high proficiency across a wide range of in vitro/ in vivo DMPK technologies and are capable of initiating new areas of investigation that are scientifically meaningful in supporting drug discovery projects
  • You monitor project progress with CROs and provide timely and valuable guidance to enable studies being executed appropriately
  • You support human dose projection calculations and support clinical pharmacology trial design based on DDI risk analysis based on nonclinical data and refining based on clinical data


What you'll bring to the table
To make the most of this role and truly thrive, you should have:

  • You hold a PhD in Drug Metabolism/ Pharmacokinetics or related discipline
  • You have demonstrated extensive experience in conducting/ managing DMPK studies (in vitro and in vivo) at CROs
  • You have demonstrated knowledge in interpreting met-id data and proposing metabolic pathways across species
  • You have experience or knowledge in bioanalytical methods and technologies for small molecules and biologics and in biomarker assays
  • You have experience in working and delivering projects within highly outsourced and matrixed environments across diverse geographies and working cultures
  • You have a proven track record in leading and working in teams based upon a matrix reporting
  • You have a broad understanding of various DMPK relevant areas such as physicochemical properties, drug metabolizing enzyme & transporter kinetics, pharmacokinetics, mechanistic biotransformation, analytical sciences and PK/dose modelling
  • You have strong interpersonal, communication, presentation, and negotiation skills


About Grünenthal

Grünenthal is a global leader in pain management and related diseases. As a science-based, privately-owned pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focussing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 29 countries across Europe, Latin America and the US. Our products are available in more than 100 countries. In 2019, Grünenthal employed around 4,700 people and achieved sales of € 1.4 bn.

Your HR contact: 
Angelika Will

Meet our teams
LinkedIn: Grunenthal Group
Instagram: @grunenthal

Meet our teams
Grunenthal Group

Apply now

Apply for Job