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Senior Toxicologist (m/f/d)

Country:  Europe
City:  Europe
Department:  Research & Development
Job ID:  37015

 

If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the live of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.

 

What the job looks like
Each day you'll enjoy a variety of challenges, such as:

  • You will have the opportunity to influence non-clinical safety success through interaction with Grünenthal R&D teams, external collaborators and vendors. These interactions will occur across multiple locations and countries and thus location of the role is flexible
  • You will be a key member of project teams with responsibility for non-clinical safety, developing overall plans for potential novel therapeutics from candidate selection through Phase III
  • You provide strategic guidance for project teams including evaluation of conclusions and potential impact of toxicology results on program and clinical/ regulatory strategy
  • You lead the development of hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams
  • You provide expert level guidance in designing and implementing preclinical safety studies at external contract research organizations (CRO)
  • You monitor toxicology and safety pharmacology studies; review, summarize, interpret and integrate complex data sets across multiple disciplines; finalize as submission-ready documents for regulatory authorities
  • You interact with regulatory authorities with in-depth knowledge on subject matter area, regulatory requirements and guidelines related to pharmacology, toxicology and nonclinical drug development in general
  • You characterize the toxicology profile of candidate molecules and provide input into investigative studies and clinical starting dose strategies
  • You are a key member of the non-clinical safety team and contribute to overall team objectives, pursuing the best science to support research and development goals.

 

What you'll bring to the table
To make the most of this role and truly thrive, you should have:

  • You hold a PhD in Toxicology or closely related field with several years’ experience in a drug discovery/ development setting of a biopharmaceutical company
  • You have a proven track record of making major contributions to the discovery of one or more marketed or in-development medicines, incl. designing, monitoring, and interpreting toxicology studies to support clinical development of candidate therapeutic agents
  • You have expert knowledge of nonclinical data packages needed to support first in human studies, clinical development and product registration
  • You are familiar with more than one of the following therapeutic modalities preferred: small or large molecules, cell and gene therapy
  • You have a theoretical and experimental background in pathology, biology, DMPK coupled with a solid foundation in quantitative pharmacology
  • You have an understanding of the regulatory process including CMC, non-clinical and clinical and the various stages of drug discovery and clinical development, as well as the ability to craft innovative solutions within the regulatory framework. 
  • You have expert knowledge of GLP regulations and experience in the oversight of contracted studies
  • You are looking for the opportunity to directly impact R&D success through the application of strong science, regulatory strategy and collaboration in the field of non-clinical safety. 

 

 

About Grünenthal

Grünenthal is a global leader in pain management and related diseases. As a science-based, privately-owned pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focussing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 29 countries across Europe, Latin America and the US. Our products are available in more than 100 countries. In 2020, Grünenthal employed around 4,500 people and achieved sales of € 1.3 bn.

Your HR contact:
Simona Frings

Meet our teams
Website: careers.grunenthal.com
LinkedIn: Grunenthal Group
Instagram: @grunenthal

Meet our teams
Website:
careers.grunenthal.com
LinkedIn:
Grunenthal Group
Instagram:
@grunenthal

Apply now

Apply for Job