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Senior Toxicologist (m/f/d)

Country:  Europe
City:  Europe
Department:  Research & Development
Job ID:  37015

 

If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the live of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.

 

What the job looks like
Each day you'll enjoy a variety of challenges, such as:

  • The opportunity to directly influence non-clinical safety success through collaboration with Grünenthal R&D teams, external experts and vendors. These   interactions will occur across multiple locations and countries and thus location of the role is flexible
  • You will be a core member of project teams with responsibility for non-clinical safety and toxicology developing overall plans for potential novel therapeutics from candidate selection through to Phase III.
  • You will provide strategic guidance for project teams including the evaluation of conclusions and potential impact of toxicology results on both program and clinical/ regulatory strategy
  • You will lead the development of hypothesis-driven investigations into the mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams
  • You will provide expert level guidance in designing and implementing preclinical safety studies at external contract research organizations (CRO)
  • You will review, summarize, interpret and integrate complex data sets across multiple disciplines and generate submission-ready documents for regulatory authorities
  • You will interact with regulatory authorities with in-depth knowledge on your subject matter area, regulatory requirements and guidelines related to pharmacology, toxicology and nonclinical drug development.
  • You will characterize the toxicology profile of candidate molecules and provide input into investigative studies and clinical starting dose strategies
  • You are a key member of the non-clinical safety team and contribute to overall team objectives, pursuing the best science to support research and development goals.

 

What you'll bring to the table

To make the most of this role and truly thrive, you should have:

  • You hold a PhD in Toxicology or related field with several years’ experience in a drug discovery/ development setting of a biopharmaceutical company
  • You have a proven track record of making impactful contributions to the discovery or development of one or more marketed or in-development medicines, including the design, monitoring, and interpretation of toxicology studies to support the clinical development of candidate therapeutic agents
  • You are looking for the opportunity to directly impact R&D success through the application of strong science, regulatory strategy and collaboration in the field of non-clinical safety. 
  • You have expert knowledge of nonclinical data packages needed to support first in human studies, clinical development and product registration
  • You are familiar with one or more of the following therapeutic modalities: small or large molecules, cell and gene therapy
  • You have an understanding of the regulatory process including CMC, non-clinical and clinical across the various stages of drug discovery and clinical development, as well as the ability to craft innovative solutions within the regulatory framework. 
  • You have expert knowledge of GLP regulations and experience in the oversight of contracted studies

 

 

About Grünenthal

Grünenthal is a global leader in pain management and related diseases. As a science-based, privately-owned pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focussing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 29 countries across Europe, Latin America and the US. Our products are available in more than 100 countries. In 2020, Grünenthal employed around 4,500 people and achieved sales of € 1.3 bn.

Your HR contact:
Simona Frings

Meet our teams
Website: careers.grunenthal.com
LinkedIn: Grunenthal Group
Instagram: @grunenthal

Meet our teams
Website:
careers.grunenthal.com
LinkedIn:
Grunenthal Group
Instagram:
@grunenthal