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Principal Pharmacometrician (m/f/d)

Country:  Germany
City:  Aachen
Department:  Research & Development
Job ID:  39141


If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the live of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.


What the job looks like

Each day you'll enjoy a variety of challenges, such as:

  • Providing expertise to all scientists and project teams by applying the most advanced computational, modeling and simulation approaches such as population PK, population PK/PD, PBPK, exposure-response modeling, disease state, IVIVC and clinical trial simulations using data generated from Omics, biomarkers, literature and/or PK, PD and DMPK experiments
  • Providing pharmacometrics leadership and contributions to regulatory interactions and documents, internal and external audiences and scientific publications
  • Analyzing internal and external data to support interpretation and decision making for project teams with regards to trial design, dose selections, safety and/or effects of the product across populations under different conditions and in comparison with competitors
  • Reaching out to collaborate with the highest quality outsourcing providers and academia partners


What you’ll bring to the table

To make the most of this role and truly thrive, you should have:

  • PhD in Pharmacometrics, Quantitative Pharmacology, Computational Biology, Statistics, Data Science or equivalent
  • Working experience in Pharma or comparable industry
  • Demonstrated profound knowledge of Model-Informed Drug Discovery and Development,
  • Knowledge of pharmaceutical sciences, and systems biology
  • Proven experience in mixed-effect and first principles modeling, model-based meta-analysis and disease modeling, population and mechanistic PK/PD modeling
  • Proven experience with R, SAS, NONMEM and other PBPK software such as Simcyp or Gastroplus
  • Being able to work in a highly matrixed structure and with a high level of outsourcing


"As an empowered member of the Data Science team you will have the opportunity to work cross-functionally in Research & Development and contribute to decision-making for new therapies for patients in need."

Sylvia Engelen, the Hiring Manager


About Grünenthal

Grünenthal is a global leader in pain management and related diseases. As a science-based, privately-owned pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focussing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 29 countries across Europe, Latin America and the US. Our products are available in more than 100 countries. In 2020, Grünenthal employed around 4,500 people and achieved sales of € 1.3 bn.

Your HR contact:
Simona Frings

Meet our teams
LinkedIn: Grunenthal Group
Instagram: @grunenthal

Meet our teams
Grunenthal Group

Apply now

Apply for Job