Discovery DMPK Lead (m/f/d)

Country:  Europe
City:  Europe
Department:  Research & Development
Job ID:  38975


If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the live of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.


As a DMPK specialist you will have the opportunity to impact the portfolio throughout the project lifecycle from early discovery through to clinical development recognising the influence DMPK has on project progression. You will be a key member of the DMPK team and help shape the DMPK strategy across the project lifecycle. With a particular focus on drug discovery, you will provide expert DMPK understanding at the interface with medicinal chemistry, pharmacology, non-clinical safety, translational sciences and clinical pharmacology.


What the job looks like

Each day you'll enjoy a variety of challenges, such as:

  • You will have the opportunity to influence DMPK success through interaction with Grünenthal R&D teams, external collaborators and vendors. These interactions will occur across multiple locations and countries and thus location of the role is flexible.
  • Being the DMPK representative on discovery project teams influencing project progression from target validation through to candidate optimisation and selection.
  • Lead the scientific and operational design, conduct, implementation, and analysis of discovery DMPK, ADME, and DDI studies to support the progression of discovery projects towards candidate selection using state-of-the art computational, in vitro and in vivo technologies.
  • Align with Medicinal Chemistry, Pharmacology and Clinical to ensure human PK, PKPD and dose predictions are undertaken to aid project decision making from target validation through to candidate selection.
  • Partner with Medicinal Chemistry to understand and optimise impact of physicochemical properties and structure on DMPK and metabolism properties within drug discovery.
  • Align with non-clinical safety to integrate PK and metabolism understanding into safety risk assessment, interpretation and quantitation/prediction of therapeutic margin of candidate molecules.
  • Engage with Development DMPK and Clinicians to ensure human PK, PKPD, ADME and DDI predictions of candidate molecules are sufficiently robust to be utilised effectively in early clinical study design and dose selection.
  • Engage with CROs and external consultants regarding conduct and interpretation of both discovery screening and investigative DMPK studies.
  • Keep abreast of DMPK science through literature and conferences and look to publish work where possible.

What you'll bring to the table

To make the most of this role and truly thrive, you should have:

  • Educated in biological or pharmacological sciences or related field with significant experience (>10 years) gained working in DMPK discipline in industry.
  • Expert technical knowledge of ADME/DMPK principles, in preclinical and clinical setting, and good understanding of their relationship to drug design, pharmacology and PKPD and also to non-clinical safety evaluation.
  • The ability to design, initiate and oversee discovery DMPK/ADME studies at CROs with timely delivery of data and interpretation that drives DMPK optimization.
  • A track record of developing and applying state-of-the-art DMPK technologies to drive scientific understanding and project decision-making.
  • A track record of interpretation and reporting of DMPK studies to support decision making.
  • Relevant experience working as a DMPK representative on discovery project teams.
  • Experiences in pharmacokinetic analysis with experience in use of software such as Phoenix/WinNonLin PK. A good understanding of PBPK modelling and industry standard software to use.
  • A good understanding of PKPD principles and the use of PKPD/QSP in translation to clinical patient setting.
  • Excellent written and communication skills.
  • Demonstrated ability to work in a matrix environment, multi-task, meet deadlines and deal with evolving priorities. You have a curious mindset and are comfortable challenging the status quo and following the science



About Grünenthal

Grünenthal is a global leader in pain management and related diseases. As a science-based, privately-owned pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focussing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 29 countries across Europe, Latin America and the US. Our products are available in more than 100 countries. In 2020, Grünenthal employed around 4,500 people and achieved sales of € 1.3 bn.

Your HR contact:
Simona Frings

Meet our teams
Website: careers.grunenthal.com
LinkedIn: Grunenthal Group
Instagram: @grunenthal

Meet our teams
Grunenthal Group